Ортофосфаты церия(IV) и нанокристаллический диоксид церия: селективная токсичность к клеткам меланомы

Нанокристаллический диоксид церия является многообещающим неорганическим УФ-фильтром в составе солнцезащитных средств благодаря высокому коэффициенту поглощению УФ-излучения и отсутствию токсичности по отношению к нормальным клеткам. Кроме того, наноразмерный CeO₂ демонстрирует селективную цитотоксичность по отношению к раковым клеткам, поэтому церийсодержащие материалы в настоящее время рассматриваются для создания профилактических и лечебных композиций. Взаимодействие наночастиц диоксида церия с клеточными мембранами и с фосфат-содержащими компонентами солнцезащитных композиций вызывает очевидный интерес к биосовместимости фосфатов церия(IV). Кристаллические ортофосфаты церия(IV) могут стать многообещающей альтернативой наноразмерному CeO₂ благодаря их низкой растворимости, высокой редокс-стабильности и УФ-защитным свойствам. Однако на сегодняшний день нет информации об их токсичности по отношению к раковым клеткам. В данной работе с использованием тестов MTT, Live/Dead и MMP мы впервые продемонстрировали ингибирующее влияние ортофосфатов церия(IV) Ce(PO₄)(HPO₄)_0.5(H₂O)_0.5 и NH₄Ce₂(PO₄)₃ на клеточную линию меланомы мыши B16/F10 in vitro, сопоставимое с действием наноразмерного CeO₂, при высоких (500–1000 мкг/мл) концентрациях. 

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