Cerium dioxide nanoparticles modulate the oxidative metabolism of neutrophils upon blood irradiation with a pulsed broadband UV source
M. M. Sozarukova,
P. A. Chilikina,
D. O. Novikov,
E. V. Proskurnina,
A. E. Baranchikov,
V. K. Ivanov https://doi.org/10.17586/2220-8054-2023-14-6-644-651
Abstract
The effect of CeO2 nanoparticles on the oxidative activity of neutrophils under UV irradiation with a pulsed broadband UV source (210 mJ/cm2) was analyzed. The effects of citrate-stabilized CeO2 sol on spontaneous and stimulated by phorbol-12-myristate-13-acetate (PMA) and N-formylmethionyl-leucyl-phenylalanine (fMLP) luminol-dependent chemiluminescence of neutrophils were evaluated. The activating effect of CeO2 nanoparticles on the spontaneous and suppressive effect on the stimulated chemiluminescence of blood neutrophils from apparently healthy donors was shown, with the most pronounced activating effect of CeO2 nanoparticles revealed in the blood sample with initially high radical-producing cell activity. Under UV irradiation of blood at a dose of 210 mJ/cm2 CeO2 nanoparticles enhance both spontaneous and stimulated radical-producing function of neutrophils. Probably, the suppressive and activating effects of citrate-stabilised cerium dioxide sol may be due to the antioxidant activity of CeO2 nanoparticles with respect to hypochlorite ions and prooxidant activity with respect to hydrogen peroxide.
Keywords
nanozymes,
cerium dioxide nanoparticles,
neutrophils,
UV radiation,
pulsed xenon UV lamp,
chemiluminescence
Supporting agencies: This work was supported by the Russian Science Foundation (project 21-73-00251).
About the Authors
M. M. Sozarukova
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Madina M. Sozarukova
Leninsky av., 31, Moscow, 119991
P. A. Chilikina
Scientific and Industrial Enterprise “MELITTA” Ltd
Russian Federation
Russian Federation
Polina A. Chilikina
Miklukho-Maklaya Str., 16/10, Moscow, 117997
D. O. Novikov
Joint Stock Company “Experimental Factory for Scientific Engineering of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Dmitry O. Novikov
Moscow region, Chernogolovka
E. V. Proskurnina
Research Centre for Medical Genetics
Russian Federation
Russian Federation
Elena V. Proskurnina
ul. Moskvorechye 1, Moscow, 115522
A. E. Baranchikov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Alexander E. Baranchikov
Leninsky av., 31, Moscow, 119991
V. K. Ivanov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Vladimir K. Ivanov
Leninsky av., 31, Moscow, 119991
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Review
For citations:
Sozarukova M.M., Chilikina P.A., Novikov D.O., Proskurnina E.V., Baranchikov A.E., Ivanov V.K. Cerium dioxide nanoparticles modulate the oxidative metabolism of neutrophils upon blood irradiation with a pulsed broadband UV source. Nanosystems: Physics, Chemistry, Mathematics. 2023;14(6):644-651. https://doi.org/10.17586/2220-8054-2023-14-6-644-651
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