Наночастицы диоксида церия модулируют оксидативный метаболизм нейтрофилов при облучении крови импульсным широкополосным источником УФ-излучения

Проведен анализ влияния наночастиц СеО₂ на оксидативную активность нейтрофилов при облучении импульсным широкополосным источником УФ-излучения (210 мДж/см₂). Оценены эффекты цитрат-стабилизированного золя СеО₂ на спонтанную и стимулированную с помощью форбол-12-миристат-13-ацетата (ФМА) и N-формилметионил-лейцил-фенилаланина (фМЛФ) люминол-зависимую хемилюминесценцию нейтрофилов. Показано активирующее влияние наночастиц СеО₂ на спонтанную хемилюминесценцию и супрессорное действие на стимулированную хемилюминесценцию нейтрофилов крови практически здоровых доноров, при этом наиболее выраженный активирующий эффект нанодисперсный СеО2 проявляет в отношении образца крови с изначально высокой радикал-продуцирующей активностью клеток. При УФ-облучении крови в дозе 210 мДж/см² наночастицы СеО₂ усиливают как спонтанную, так и стимулированную радикал-продуцирующую функцию нейтрофилов. Супрессорное и активирующее действие цитратного золя диоксида церия может быть обусловлено антиоксидантной активностью наночастиц СеО₂ по отношению к гипохлорит-ионам и прооксидантной активностью по отношению к пероксиду водорода, соответственно

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