Медленное высвобождение цинка из карбоксиметилцеллюлозных гелей, наполненных гуминовыми нанокомпозитами оксида цинка

Цель работы - исследование нанокомпозитов оксида цинка и гуминовых веществ (ГВ), направленном на оценку возможности их применении для заживления ран в виде фармацевтически активных компонентов гидрогелей. Наночастицы оксида цинка синтезировали в присутствии различных концентраций гуминовых веществ. Анализ полученных нанокомпозитов вели с использованием методов рентгеновской дифрактометрии, ПЭМ, СЭМ и УФ-видимой спектроскопии. Найдено, что размер наночастиц ZnO  уменьшался от 50 до 15 нм по мере увеличения концентрации ГВ. ПЭМ-изображения показали присутствие звездообразных агрегатов частиц ZnO размером 200-500 нм, которые формировались в отсутствие гуминовых веществ (ГВ). В присутствии ГВ наблюдалось образование бесформенных частиц с размерами в диапазоне от 20 до 200 нм. Спектры поглощения показали характерный пик ZnO около 360 нм, который смещался наряду с увеличением концентрации ГВ. Согласно выполненным расчетам, ширина запрещенной зоны наночастиц ZnO увеличилась с 3,35 эВ до 3,51 эВ по мере увеличения концентрации ГВ до 15 г/л. Это может указывать на образование дефектов в кристаллах ZnO в результате взаимодействия с ГВ. Синтезированные нанокомпозиты ZnO-HS были использованы для заполнения гидрогелей карбоксиметилцеллюлозы (КМЦ). Для имитации состояния раны были проведены исследования высвобождения ионов цинка из геля в бульон Мюллера-Хинтона и 0.1М ацетатный буфер. Динамика концентрации Zn в приемных растворах показала замедленное высвобождение с течением времени, что делает эти гели потенциально пригодными для длительного лечения ран.

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