Synthesis of redox-active Ce0.75Bi0.15Tb0.1F3 nanoparticles and their biocompatibility study in vitro
https://doi.org/10.17586/2220-8054-2024-15-2-260-267
Abstract
Cerium fluoride (CeF3) nanoparticles (NPs), being a unique nanozyme and redox-active nanomaterial, show high promise for advanced biomedical applications. Doping of CeF3 NPs with the other chemical elements allow one to increase their catalytic activity, impart them new functional properties, and also to increase the efficiency of their interaction with ionizing radiation, which is important in the development of novel nanoradiosensitizers. In this article, we synthesized citrate-stabilized Ce0.75Bi0.15Tb0.1F3 nanoparticles, which demonstrate high colloidal stability, have good luminescent properties and radiation-induced redox activity. Cytotoxicity analysis of Ce0.75Bi0.15Tb0.1F3 NPs using normal and tumor cells in vitro showed the sensitivity of B16/F10 and EMTP6 tumor cell lines to the nanoparticles at high concentrations (0.5 – 1 mM). Obtained experimental results allow us to consider Ce0.75Bi0.15Tb0.1F3 nanoparticles as a possible platform for the development of a new class of nanoradiosensitizers for radiation therapy purposes.
Supporting agencies: The work was supported by the Russian Science Foundation (project no. 22-73-10231, https://rscf.ru/project/22-73-10231/ ).
About the Authors
N. N. Chukavin
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Nikita N. Chukavin.
142290
D. D. Kolmanovich
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Danil D. Kolmanovich.
142290
A. D. Filippova
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Arina D. Filippova.
Moscow, 119991
M. A. Teplonogova
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Maria A. Teplonogova.
Moscow, 119991
V. K. Ivanov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Vladimir K. Ivanov.
Moscow, 119991
A. L. Popov
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Anton L. Popov.
142290
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Review
For citations:
Chukavin N.N., Kolmanovich D.D., Filippova A.D., Teplonogova M.A., Ivanov V.K., Popov A.L. Synthesis of redox-active Ce0.75Bi0.15Tb0.1F3 nanoparticles and their biocompatibility study in vitro. Nanosystems: Physics, Chemistry, Mathematics. 2024;15(2):260-267. https://doi.org/10.17586/2220-8054-2024-15-2-260-267
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