The first issue of the journal was published in 2010. In 2011, 4 issues were published, and since 2012, 6 issues of the journal have been published per year. Since 2011, the journal has been included in the List of the Higher Attestation Commission of journals intended for publishing the results of candidate and doctoral dissertations. Since 2016, the journal "Nanosystems: Physics, Chemistry, Mathematics" has been included in the Emerging Sources Citation Index (ESCI) database, which is part of the Web of Science Core Collection. Articles indexed in ESCI are counted as WoS publications in all Russian scientific foundations. Since 2020, the journal has been indexed in SCOPUS.