Экспериментальное исследование реологических свойств ниосомальных дисперсий
https://doi.org/10.17586/2220-8054-2023-14-2-195-201
Аннотация
В данной работе исследованы реологические свойства ниосомальных дисперсий различных концентраций в диапазоне температур 30-600С. Были проведены эксперименты по определению коэффициента вязкости и значений энергии активации. Установлено, что течения ниосомальных дисперсий в исследуемом диапазоне температур и скоростей сдвига проявляют свойства ньютоновских жидкостей. Определены рациональные условия получения стабильных гомогенных ниосомальных дисперсий со средним размером везикул 80-150 нм.
Об авторах
Е. И. Дискаева
Department of Physics and Mathematics, Stavropol State Medical University
Россия
Россия
О. В. Вечер
Department of Physics and Mathematics, Stavropol State Medical University
Россия
Россия
Е. Н. Дискаева
Branch of the Federal State Budget Educational Institution of Higher Education “MIREA– Russian Techno logical University”
Россия
Россия
И. А. Базиков
Department of Microbiology, Stavropol State Medical University
Россия
Россия
К. С. Эльбекьян
Department of General and Biological Chemistry, Stavropol State Medical University
Россия
Россия
Список литературы
1. Pal’cev M.A. Nanotechnologies in medicine and pharmacology. Remedium, 2008, 9, P. 6–11.
2. Cho H.J., Yoon I.S., Yoon H.Y., et al. Polyethylene glycolconjugated hyaluronic acid-ceramide self-assembled nanoparticles for targeted delivery of doxorubicin. Biomaterials, 2012, 33, P. 1190–1200.
3. Dutta R.C. Drug carriers in pharmaceutical design: promises and progress. Current Pharmaceutical Design, 2007, 13 (7), 761.
4. Martins S., Sarmento B., Ferreira D.C., Souto E.B. Lipid-based colloidal carriers for peptide and protein delivery—liposomes versus lipid nanopar ticles. Int. J. of Nanomedicine, 2007, 2 (4), P. 595–607.
5. Md. Sanower Hossain, Farahidah Mohamed,Mohd Affendi Mohd Shafri. Poly (trimethylene carbonate-co-caprolactone): An emerging drug deliv ery nanosystem in pharmaceutics. Biomaterials and Biomechanics in Bioengineering, 2020, 5 (1), P. 65–86.
6. Naggar V.F., Elgamal S.S., Allam A.N. Proniosomes as a Stable Carrier for Oral Acyclovir: Formulation and Physicochemical Characterization. J. of American Science, 2012, 8 (9), P. 417–428.
7. Dharashive V.M., Yelam K.V.N., Devine S.S. Niosomes: as a targeted drug delivery system. Int. J. of Research in Pharmacy and Chemistry, 2015, 5 (4), P. 582–589.
8. Lombardo D., Kiselev M.A., Caccamo M.T. Smart nanoparticles for drug delivery application: development of versatile nanocarrier platforms in biotechnology and nanomedicine. J. of Nanomaterials, 2019, P. 1–26.
9. Rajera R., Nagpal K., Singh S.K., Mishra D.N. Niosomes: a controlled and novel drug delivery system. Biological and Pharmaceutical Bulletin, 2011, 34 (7), P. 945–953.
10. Pardakhty A., Moazeni E. Nano-niosomes in drug, vaccine and gene delivery: a rapid overview. Nanomedicine J., 2013, 1 (1), P. 1–12.
11. Madni A., Sarfraz M., Rehman M., Ahmad M., Akhtar N., Ahmad S., Tahir N., Ijaz S., Al-Kassas R., L¨ obenberg R. Liposomal drug delivery: a versatile platform for challenging clinical applications. J. of Pharmacy and Pharmaceutical Sciences, 2014, 17 (3), P. 401–426.
12. Fofaria N.M., Quattal H.S.S., Liu X., Srivastava S.K. Nanoemulsion formulations for anti-cancer agent piplartine– characterization, toxicological, pharmacokinetics and efficacy studies. Int. J. of Pharmaceutics, 2016, 98(1-2), P. 12–22.
13. Kaur K., Jain S., Sapra B., Tiwary A.K. Niosomal gel for site-specific sustained delivery of anti-arthritic drug: in vitro-in vivo evaluation. Current Drug Delivery, 2007, 4 (4), P. 276–282.
14. Sattuwar P.M., Khandare J.N., Nahde V.S. Niosomal delivery of Ketonozole. Indian Drugs, 2001, 38 (12), P. 620–623.
15. Popova E.V., Beltyukov P.P., Radilov A.S. Modern trends in the development and production of nanoscale systems for the delivery of medicinal compounds. Scientific and technical bulletin of information technologies, mechanics and optics, 2020, 20 (2), P. 206–222.
16. Yoshioka T., Sternberg B., Florence A.T. Preparation and properties of vesicles (niosomes) of sorbitan monoester (Span 20, 40, 60 and 80) and sorbitan trimester (Span 85). Int. J. of Pharmaceutics, 1994, 105 (1), P. 1–6.
17. Ghafelehbashi R., Akbarzadeh I., Tavakkoli Yaraki M., Lajevardi A., Fatemizadeh M., Heidarpoor Saremi L. Preparation, physicochemical prop erties, in vitro evaluation and release behavior of cephalexin-loaded niosomes. Int. J. of Pharmaceutics, 2019, 569, 118580.
18. Anupriya Kapoor. An overview on niosomes. A novel vesicular approach for ophthalmic drug delivery. Pharma Tutor, 2016, 4 (2), P. 28–33.
19. Vecher O.V., Diskaeva E.I., Bazikov I.A., Elbekyan K.S., Diskaeva E.N. Study of some rheological properties of niosomal dispersions based on PEG-12 dimethicone. Advances in Natural Nanoscience and Nanotechnology, 2020, 11 (4).
20. Diskaeva E.I., Vecher O.V., Bazikov I.A., Elbekyan K.S., Diskaeva E.N. Dependence of the viscosity coefficient of the niosomal dispersion on the temperature and particle size of the dispersed phase. Acta Polynechnica, 2021, 61 (2), P. 336–341.
21. Vasir J.K., Reddy M.K., Labhasetwar V.D. Nanosystems in drug targeting: opportunities and challenges. Current Nanoscience, 2005, 1 (1), P. 47–64.
22. Paolino D., Muzzalupo R., Ricciardi A., Celia C., Picci N., Fresta M. In vitro and in vivo evaluation of Bola-surfactant containing niosomes for transdermal delivery. Biomedical Microdevices, 2007, 9 (4), P. 421–433.
23. Godic A. New approaches to psoriasis treatment. A review. Acta Dermatovenerologia 2004, 13 (2), P. 50–57.
24. Kazi Masud Karim, Asim Sattwa Mandal, Nikhil Biswas, Arijit Guha, Sugata Chatterjee, Mamata Behera. Niosome: A future of targeted drug delivery systems. J. of Advanced Pharmaceutical Technology & Research, 2011, 1 (4), P. 374–380.
25. Bibik E.E. Rheology of Dispersed Systems. LGU, Leningrad, 1981, 171 p.
26. Matveenko V.N., Kirsanov E.A. Viscosity and structure of dispersed systems. Moscow University Chemistry Bulletin, 2011, 66, P. 199–201.
27. Malkin A.Y., Isayev A.I. Rheology: concepts, methods, and applications, Elsevier Science, 2017, 500 p.
28. Jhili Mishra, Jitendriya Swain , Ashok Kumar Mishra. Probing the temperature-dependent changes of the interfacial hydration and viscosity of Tween 20: cholesterol (1:1) niosome membrane using fisetin as a fluorescent molecular probe. Physical Chemistry Chemical Physics, 2018, 20, P. 13279–13289.
29. Bazikov I.A., Omelyanchuk P.A. The method of delivery of biologically active substances with the help of niosomes RF patent 2320323, 2008.
30. Diskaeva E.I., Vecher O.V., Bazikov I.A., Vakalov D.S. Particle size analysis of niosomes as a function of temperature. Nanosystems: Phys. Chem. Math. 2018, 9 (2), P. 290–294.
31. Diskaeva E.I., Vecher O.V., Bazikov I.A., Maltsev A.N. Dispersion analysis of niosomes different composition. J. of Nanoparticle Research, 2019, 21 (1), P. 21–23.
Рецензия
Для цитирования:
Дискаева Е.И., Вечер О.В., Дискаева Е.Н., Базиков И.А., Эльбекьян К.С. Экспериментальное исследование реологических свойств ниосомальных дисперсий. Наносистемы: физика, химия, математика. 2023;14(2):195-201. https://doi.org/10.17586/2220-8054-2023-14-2-195-201
For citation:
Diskaeva E.I., Vecher O.V., Diskaeva E.N., Bazikov I.A., Elbekyan K.S. Experimental investigation of rheological properties of niosomal dispersions. Nanosystems: Physics, Chemistry, Mathematics. 2023;14(2):195-201. https://doi.org/10.17586/2220-8054-2023-14-2-195-201
Просмотров:
3
Послать статью по эл. почте 