Bioavailability of nanoemulsions modified with curcumin and cerium dioxide nanoparticles
A. D. Shirokikh,
V. A. Anikina,
E. A. Zamyatina,
E. V. Mishchenko,
M. Yu. Koroleva,
V. K. Ivanov,
N. R. Popova https://doi.org/10.17586/2220-8054-2023-14-1-89-97
Abstract
In this work, the physicochemical properties and biological activity of nanoemulsions prepared from paraffin oil and stabilized by nonionic surfactants as carriers of curcumin and cerium dioxide nanoparticles were studied. An analysis of the results showed that curcumin was incorporated into the oil droplets while cerium dioxide nanoparticles were adsorbed on the surface of oil droplets. The nanoemulsion droplet size did not exceed 100 nm. The absence of toxicity to mouse embryonic fibroblasts in vitro and after a single intraperitoneal injection to mice in vivo makes the nanoemulsions promising drug carriers for advanced biomedical applications.
Supporting agencies: This research has been supported by the Russian Science Foundation (project 22-6300082).
About the Authors
A. D. Shirokikh
Mendeleev University of Chemical Technology
Russian Federation
Russian Federation
Anastasiya D. Shirokikh, Department of Nanomaterials and Nanotechnology,
9, Miusskaya sq., Moscow, 125047.
V. A. Anikina
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Viktoriia A. Anikina,
Institutskaya str., 3, Pushchino, 142290.
E. A. Zamyatina
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elizaveta A. Zamyatina,
Institutskaya str., 3, Pushchino, 142290.
E. V. Mishchenko
Mendeleev University of Chemical Technology
Russian Federation
Russian Federation
Ekaterina V. Mishchenko, Department of Nanomaterials and Nanotechnology,
Miusskaya sq., 9, Moscow, 125047.
M. Yu. Koroleva
Mendeleev University of Chemical Technology
Russian Federation
Russian Federation
Marina Y. Koroleva, Department of Nanomaterials and Nanotechnology,
Miusskaya sq., 9, Moscow, 125047.
V. K. Ivanov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Vladimir K. Ivanov,
Leninskiy prosp., 31, Moscow, 119991.
N. R. Popova
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Nelli R. Popova,
Institutskaya str., 3, Pushchino, 142290.
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Review
For citations:
Shirokikh A.D., Anikina V.A., Zamyatina E.A., Mishchenko E.V., Koroleva M.Yu., Ivanov V.K., Popova N.R. Bioavailability of nanoemulsions modified with curcumin and cerium dioxide nanoparticles. Nanosystems: Physics, Chemistry, Mathematics. 2023;14(1):89-97. https://doi.org/10.17586/2220-8054-2023-14-1-89-97
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