Биодоступность наноэмульсий, модифицированных куркумином и наночастицами диоксида церия
А. Д. Широких,
В. А. Аникина,
Е. А. Замятина,
Е. В. Мищенко,
М. Ю. Королева,
В. К. Иванов,
Н. Р. Попова https://doi.org/10.17586/2220-8054-2023-14-1-89-97
Аннотация
В работе изучены физико-химические свойства и биологическая эффективность наноэмульсий с углеводородным маслом, стабилизированных неионогенными поверхностно-активными веществами, как носителей активных веществ - куркумина и наночастиц диоксида церия. Анализ физико-химических свойств показал, что куркумин встраивается в структуру масляных капель, а наночастицы диоксида церия адсорбируются на их поверхности. Размер капель наноэмульсий не превышал 100 нм. Отсутствие токсичности в отношении эмбриональных фибробластов мыши in vitro и после однократного внутрибрюшинного введения мышам in vivo делает их перспективными носителями лекарственных средств различного биологического назначения.
Об авторах
А. Д. Широких
Mendeleev University of Chemical Technology
Россия
Россия
Москва.
В. А. Аникина
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
Москва.
Е. А. Замятина
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
Москва.
Е. В. Мищенко
Mendeleev University of Chemical Technology
Россия
Россия
Москва.
М. Ю. Королева
Mendeleev University of Chemical Technology
Россия
Россия
Москва.
В. К. Иванов
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Россия
Россия
Москва.
Н. Р. Попова
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
Москва.
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Рецензия
Для цитирования:
Широких А.Д., Аникина В.А., Замятина Е.А., Мищенко Е.В., Королева М.Ю., Иванов В.К., Попова Н.Р. Биодоступность наноэмульсий, модифицированных куркумином и наночастицами диоксида церия. Наносистемы: физика, химия, математика. 2023;14(1):89-97. https://doi.org/10.17586/2220-8054-2023-14-1-89-97
For citation:
Shirokikh A.D., Anikina V.A., Zamyatina E.A., Mishchenko E.V., Koroleva M.Yu., Ivanov V.K., Popova N.R. Bioavailability of nanoemulsions modified with curcumin and cerium dioxide nanoparticles. Nanosystems: Physics, Chemistry, Mathematics. 2023;14(1):89-97. https://doi.org/10.17586/2220-8054-2023-14-1-89-97
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