Cerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effects
https://doi.org/10.17586/2220-8054-2023-14-5-560-570
Abstract
Cerium oxide nanoparticles (CeNPs) are among the most promising materials with pH-sensitive redox-activity for biomedical nanotechnologies. CeNPs are known to reduce the toxicity of the chemotherapeutic drug doxorubicin (DOX) for normal cells. Here we have proposed and analyzed a new hybrid cerium/silica containing SiNPs@DOX@CeNPs nanocomposite. We showed that the average size of the nanocomposite is 190 nm and it has a spherical shape. The SiNPs@DOX@CeNPs nanocomposite provides effective synergistic anticancer activity of CeNPs with doxorubicin (DOX), as well as selective toxicity against human osteosarcoma (MNNG/HOS) cells in vitro. The SiNPs@DOX@CeNPs nanocomposite may be a good candidate to increase the effectiveness of cancer doxorubicin chemotherapy.
Keywords
nanocomposites,
silica nanoparticles,
cerium oxide nanoparticles,
biomedical application,
characterization,
drug delivery
Supporting agencies: This research was funded by the Russian Science Foundation, grant number 22-63- 00082 and performed using the equipment of the Joint Research Centre for Physical Methods of Research at Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences (JRC PMR IGIC RAS).
About the Authors
E. A. Zamyatina
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elizaveta A. Zamyatina
Institutskaya str., 3, Pushchino, 142290
S. Yu. Kottsov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Sergey Yu. Kottsov
Leninskiy prosp., 31, Moscow, 119991
V. A. Anikina
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Viktoriia A. Anikina
Institutskaya str., 3, Pushchino, 142290
A. L. Popov
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Anton L. Popov
Institutskaya str., 3, Pushchino, 142290
M. P. Shevelyova
Institute for Biological Instrumentation of the Russian Academy of Sciences
Russian Federation
Russian Federation
Marina P. Shevelyova
Institutskaya str., 7, Pushchino, 142290
N. R. Popova
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Nelli R. Popova
Institutskaya str., 3, Pushchino, 142290
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Review
For citations:
Zamyatina E.A., Kottsov S.Yu., Anikina V.A., Popov A.L., Shevelyova M.P., Popova N.R. Cerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effects. Nanosystems: Physics, Chemistry, Mathematics. 2023;14(5):560-570. https://doi.org/10.17586/2220-8054-2023-14-5-560-570
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