Нанокомпозит оксид церия-оксид кремния как мультимодальная платформа для синергетического противоракового действия
https://doi.org/10.17586/2220-8054-2023-14-5-560-570
Аннотация
Наночастицы диоксида церия являются одними из наиболее перспективных материалов, обладающих pH-чувствительной окислительно-восстановительной активностью, применяющихся в биомедицинских нанотехнологиях. CeNPs известны своей способностью снижать токсичность химиотерапевтического препарата доксорубицина (DOX) при его инкубации с нормальными клеточными культурами. В работе предложен новый гибридный нанокомпозит SiNPs@DOX@CeNPs. Показано, что нанокомпозит обладал сферической формой, а его размер составил 190 нм. Нанокомпозит SiNPs@DOX@CeNPs обеспечивает синергетическую противоопухолевую активность в отношении клеточной культуры остеосаркомы человека (MNNG/HOS) in vitro. Нанокомпозит SiNPs@DOX@CeNPs может являться хорошим кандидатом для повышения эффективности противоопухолевой терапии с использованием DOX.
Об авторах
Е. А. Замятина
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
С. Ю. Котцов
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Россия
Россия
В. А. Аникина
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
А. Л. Попов
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
М. П. Шевелева
Institute for Biological Instrumentation of the Russian Academy of Sciences
Россия
Россия
Н. Р. Попова
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
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Рецензия
Для цитирования:
Замятина Е.А., Котцов С.Ю., Аникина В.А., Попов А.Л., Шевелева М.П., Попова Н.Р. Нанокомпозит оксид церия-оксид кремния как мультимодальная платформа для синергетического противоракового действия. Наносистемы: физика, химия, математика. 2023;14(5):560-570. https://doi.org/10.17586/2220-8054-2023-14-5-560-570
For citation:
Zamyatina E.A., Kottsov S.Yu., Anikina V.A., Popov A.L., Shevelyova M.P., Popova N.R. Cerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effects. Nanosystems: Physics, Chemistry, Mathematics. 2023;14(5):560-570. https://doi.org/10.17586/2220-8054-2023-14-5-560-570
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